Regenerative Medicine
Tirzepatide (Zepbound / Mounjaro)
Dual GIP/GLP-1 agonist — the most effective weight loss medication available, averaging 18–22% body weight reduction in published trials.
Tirzepatide is a dual agonist — it activates both GLP-1 and GIP receptors. This produces greater weight loss than semaglutide on average (18–22% vs 12–15% across head-to-head data) and slightly stronger glycemic control. It's the active ingredient in Mounjaro (FDA-approved for type 2 diabetes) and Zepbound (FDA-approved for weight loss). At Elements, our tirzepatide programs include the medication, structured lifestyle support, and ongoing labs.
Tirzepatide protocols at Elements follow the same structured framework as semaglutide: initial consultation, baseline labs, dose titration starting at 2.5mg weekly and progressing to maintenance over 16–20 weeks. We pair medication with protein targets (typically 0.8–1g per pound goal body weight) and resistance training prescription to preserve lean mass. Side effects mirror semaglutide but tend to be slightly more pronounced during early titration — GI symptoms peak in weeks 1–2 of each dose increase. Less common: pancreatitis (rare), gallbladder issues. Contraindications match semaglutide. Pricing: brand-name (Zepbound) typically runs $1,000–$1,300/month without insurance, often covered with diabetes diagnosis; compounded tirzepatide where available runs $400–$700/month. We stay current on FDA compounding guidance and adjust supply accordingly.
Key Benefits
Common Questions
Frequently asked
Why does tirzepatide produce more weight loss than semaglutide?
Tirzepatide is a dual agonist — it activates both GLP-1 and GIP receptors. The combined receptor activation produces stronger appetite suppression and metabolic effects. In head-to-head SURMOUNT trials, tirzepatide averaged 18–22% body weight loss vs 12–15% for semaglutide.
How is the dose titrated?
Standard tirzepatide titration: 2.5mg weekly → 5mg → 7.5mg → 10mg → 12.5mg → 15mg. Each dose is held for at least 4 weeks. Most patients reach effective dose at 7.5–10mg.
Tirzepatide vs semaglutide — how do I choose?
Tirzepatide produces more weight loss on average but is typically more expensive. Semaglutide has a longer track record. Many patients start on semaglutide for cost reasons and switch to tirzepatide if results plateau or weight loss is the primary goal. Janessa walks through both options at consultation.
Are side effects different from semaglutide?
Generally similar (GI symptoms during titration), but tirzepatide users sometimes report slightly more pronounced early nausea. The effect is dose-dependent and resolves at maintenance dose for most patients.
Who shouldn't use tirzepatide?
Same contraindications as semaglutide: personal/family history of medullary thyroid carcinoma, MEN2 syndrome, severe gastroparesis, pancreatitis history, pregnancy.
Start here
Book now to talk through whether tirzepatide (zepbound / mounjaro) is the right fit for your goals, timeline, and recovery plan.
Book now →Related Protocols